Offense
| # | Name | Pos | Ht | Wt | Exp | College | Status |
| 55 | Olu Oluwatimi | C | 6'3" | 309 lbs | 3 | Michigan | Active |
| 61 | Jalen Sundell | C | 6'5" | 300 lbs | 2 | North Dakota State | Active |
| 62 | Federico Maranges | C | 6'3" | 302 lbs | R | Florida Atlantic | Practice Squad |
| 38 | Brady Russell | FB | 6'3" | 250 lbs | 3 | Colorado | Active |
| 64 | Christian Haynes | G | 6'3" | 318 lbs | 2 | Connecticut | Active |
| 75 | Anthony Bradford | G | 6'4" | 335 lbs | 3 | LSU | Active |
| 76 | Grey Zabel | G | 6'6" | 316 lbs | R | North Dakota State | Active |
| 77 | Bryce Cabeldue | G | 6'4" | 306 lbs | R | Kansas | Reserve |
| 78 | Mason Richman | G | 6'5" | 307 lbs | R | Iowa | Active |
| — | Shane Lemieux | G | 6'4" | 310 lbs | 6 | Oregon | Practice Squad |
| 67 | Charles Cross | OT | 6'5" | 317 lbs | 4 | Mississippi State | Active |
| 72 | Abraham Lucas | OT | 6'6" | 322 lbs | 4 | Washington State | Active |
| 74 | Josh Jones | OT | 6'7" | 339 lbs | 6 | Houston | Active |
| 79 | Amari Kight | OT | 6'7" | 318 lbs | R | UCF | Reserve |
| — | Logan Brown | OT | 6'6" | 312 lbs | R | Kansas | Practice Squad |
| 2 | Drew Lock | QB | 6'4" | 228 lbs | 7 | Missouri | Active |
| 6 | Jalen Milroe | QB | 6'2" | 216 lbs | R | Alabama | Active |
| 14 | Sam Darnold | QB | 6'3" | 225 lbs | 8 | USC | Active |
| — | Cam Akers | RB | 5'10" | 217 lbs | 5 | Florida State | Active |
| 9 | Kenneth Walker III | RB | 5'9" | 211 lbs | 4 | Michigan State | Active |
| 25 | Kenny McIntosh | RB | 6'0" | 211 lbs | 3 | Georgia | Reserve |
| — | Velus Jones Jr. | RB | 6'0" | 200 lbs | 5 | Tennessee | Active |
| 26 | Zach Charbonnet | RB | 6'1" | 214 lbs | 3 | UCLA | Reserve |
| 31 | Jacardia Wright | RB | 6'0" | 218 lbs | R | Missouri State | Practice Squad |
| 36 | George Holani | RB | 5'10" | 210 lbs | 2 | Boise State | Active |
| 40 | Robbie Ouzts | RB | 6'3" | 274 lbs | R | Alabama | Active |
| 18 | Elijah Arroyo | TE | 6'5" | 254 lbs | R | Miami | Active |
| 81 | Eric Saubert | TE | 6'5" | 253 lbs | 8 | Drake | Active |
| 88 | AJ Barner | TE | 6'6" | 251 lbs | 2 | Michigan | Active |
| 89 | Nick Kallerup | TE | 6'5" | 266 lbs | R | Minnesota | Active |
| 10 | Cooper Kupp | WR | 6'2" | 205 lbs | 9 | Eastern Washington | Active |
| — | Courtney Jackson | WR | 5'11" | 189 lbs | R | Arkansas State | Practice Squad |
| 11 | Jaxon Smith-Njigba | WR | 6'0" | 197 lbs | 3 | Ohio State | Active |
| 15 | Tory Horton | WR | 6'2" | 196 lbs | R | Colorado State | Reserve |
| 19 | Jake Bobo | WR | 6'4" | 207 lbs | 3 | UCLA | Active |
| 22 | Rashid Shaheed | WR | 6'0" | 180 lbs | 4 | Weber State | Active |
| 35 | Montorie Foster Jr | WR | 6'0" | 185 lbs | R | Michigan State | Practice Squad |
| 82 | Cody White | WR | 6'3" | 227 lbs | 4 | Michigan State | Reserve |
| 83 | Dareke Young | WR | 6'2" | 224 lbs | 4 | Lenoir Rhyne | Active |
| 86 | Ricky White III | WR | 6'1" | 181 lbs | R | UNLV | Practice Squad |
| — | Tyler Scott | WR | 5'10" | 182 lbs | 3 | Cincinnati | TRT |
| 85 | Tyrone Broden | WR | 6'5" | 194 lbs | R | Arkansas | Practice Squad |
Defense
| # | Name | Pos | Ht | Wt | Exp | College | Status |
| 1 | Derion Kendrick | CB | 6'0" | 190 lbs | 4 | Georgia | TRT |
| 21 | Devon Witherspoon | CB | 6'0" | 185 lbs | 3 | Illinois | Active |
| 27 | Riq Woolen | CB | 6'4" | 210 lbs | 4 | Texas-San Antonio | Active |
| 28 | Nehemiah Pritchett | CB | 6'0" | 188 lbs | 2 | Auburn | Active |
| 29 | Josh Jobe | CB | 5'11" | 190 lbs | 4 | Alabama | Active |
| — | Shaquill Griffin | CB | 6'0" | 198 lbs | 9 | UCF | Practice Squad |
| 34 | Shemar Jean-Charles | CB | 5'10" | 184 lbs | 5 | Appalachian State | Practice Squad |
| 35 | Tyler Hall | CB | 5'10" | 190 lbs | 4 | Wyoming | Practice Squad |
| 94 | Mike Morris | DE | 6'6" | 295 lbs | 3 | Michigan | Active |
| 98 | Rylie Mills | DE | 6'5" | 296 lbs | R | Notre Dame | Active |
| 99 | Leonard Williams | DE | 6'5" | 310 lbs | 11 | USC | Active |
| 69 | Wy'Kevious Thomas | DT | 6'2" | 303 lbs | R | South Alabama | Practice Squad |
| 70 | J.R. Singleton | DT | 6'1" | 299 lbs | R | Iowa State | Practice Squad |
| 90 | Jarran Reed | DT | 6'3" | 315 lbs | 10 | Alabama | Active |
| 91 | Byron Murphy II | DT | 6'0" | 306 lbs | 2 | Texas | Active |
| 95 | Brandon Pili | DT | 6'3" | 334 lbs | 3 | USC | Active |
| — | DeMarcus Lawrence | LB | 6'3" | 254 lbs | 12 | Boise State | Active |
| 7 | Uchenna Nwosu | LB | 6'2" | 265 lbs | 8 | USC | Active |
| 13 | Ernest Jones | LB | 6'2" | 230 lbs | 5 | South Carolina | Active |
| 42 | Drake Thomas | LB | 5'11" | 228 lbs | 3 | N.C. State | Active |
| 44 | Chazz Surratt | LB | 6'2" | 233 lbs | 4 | North Carolina | Active |
| — | Ja'Markis Weston | LB | 6'2" | 235 lbs | R | Florida | Practice Squad |
| 48 | Tyrice Knight | LB | 6'0" | 233 lbs | 2 | Texas-El Paso | Active |
| 50 | Jamie Sheriff | LB | 6'1" | 254 lbs | 1 | South Alabama | Practice Squad |
| 51 | Jared Ivey | LB | 6'6" | 274 lbs | R | Mississippi | Active |
| 52 | Patrick O'Connell | LB | 6'1" | 231 lbs | 2 | Montana | Active |
| 53 | Boye Mafe | LB | 6'4" | 261 lbs | 4 | Minnesota | Active |
| 57 | Connor O'Toole | LB | 6'3" | 248 lbs | R | Utah | Active |
| 58 | Derick Hall | LB | 6'3" | 254 lbs | 3 | Auburn | Active |
| — | Pooh Paul Jr. | LB | 6'1" | 235 lbs | R | Mississippi | Practice Squad |
| — | Quandre Diggs | S | 5'9" | 198 lbs | 11 | Texas | Practice Squad |
| 3 | Nick Emmanwori | SAF | 6'3" | 220 lbs | R | South Carolina | Active |
| 8 | Coby Bryant | SAF | 6'1" | 193 lbs | 4 | Cincinnati | Active |
| 20 | Julian Love | SAF | 5'11" | 195 lbs | 7 | Notre Dame | Active |
| 30 | AJ Finley | SAF | 6'2" | 202 lbs | 3 | Mississippi | Reserve |
| 39 | Ty Okada | SAF | 5'11" | 193 lbs | 1 | Montana State | Active |
| 43 | Maxen Hook | SAF | 6'0" | 203 lbs | R | Toledo | Practice Squad |
Special Teams
| # | Name | Pos | Ht | Wt | Exp | College | Status |
| 5 | Jason Myers | K | 5'10" | 190 lbs | 11 | Marist | Active |
| 41 | Chris Stoll | LS | 6'2" | 255 lbs | 3 | Penn State | Active |
| 4 | Michael Dickson | P | 6'2" | 208 lbs | 8 | Texas | Active |
