Schedule →

49ers vs Seahawks recap: Deebo Samuel and Dre Greenlaw's injuries impact game

By Pro Football News Network AI-assisted••4 min read• San Francisco 49ers
Share:
PFNN Sportsbook TrainerPractise betting with no money down · Real lines, fake stakes · Track every result · Free to playStart training →

49ers Lose Deebo Samuel and Dre Greenlaw in Seahawks Clash as Murray, Maye and Jacksonville Deliver

Sunday in the NFL produced one genuinely ugly divisional game, one quarterback turning back the clock, and a special teams snap that a nose tackle had no business making. The small stuff decided the day, which is usually how it goes.

Start with the NFC West, where the San Francisco 49ers and Seattle Seahawks spent the afternoon trading body blows and disqualifications. Dre Greenlaw was ejected in the second quarter after a late hit and an ensuing head-butt on a helmetless Jones. The ejection is the cheap part. A head-butt delivered to a player who isn't wearing a helmet is exactly the flavor of unnecessary roughness the league office reviews with a fine and a suspension attached, and my read is that Greenlaw sits at least a game for it. San Francisco can't absorb that lightly: Fred Warner finished with 10 tackles in this one, and he's already carrying most of the linebacker workload. Take Greenlaw out of the room and that job gets heavier in a division where the 49ers can't afford to get slower.

The worse news came on offense. Deebo Samuel left with a hamstring injury, and a hamstring is the specific injury that punishes receivers who win with acceleration. He'd already caught 2 passes for 21 yards and returned 2 kickoffs for 50 before he was done. The shape of the offense without him is visible in the numbers: Brock Purdy went 19-of-29 for 189 yards with 2 touchdowns and 1 interception, Christian McCaffrey ran 11 times for 68 yards and a score, and George Kittle caught 5 passes for 24 yards. Five catches for 24 yards is the tell. Everything got underneath, nobody stretched the field, and that's a functional offense rather than a frightening one. I expect Jacob Cowing to pick up slot and return work if Samuel misses time, though he also lost a fumble in this game, so the 49ers are choosing between inexperience and a shrunken playbook. I'd take the shrunken playbook.

Around the league, Kyler Murray scrambled seven times in leading the Vikings to a win, his most in a game since 2020, and the temptation in Minnesota will be to file that under survival mechanism and coach it out of him. Wrong instinct. That's the version of Murray that wins football games, and the Vikings' actual job is protecting him from the hits that come with it. I expect designed runs to tick up from here, not down. I'd be wrong if the injury report starts filling up.

In Jacksonville, Jaguars nose tackle DaVon Hamilton delivered the crucial snap on Cam Little's game-winning 57-yard field goal. A kick from 57 is already at the outer edge of what most coaches will even attempt, which means the margin for a bad snap is zero, and Jacksonville got a clean one from a defensive lineman. My read: the Jaguars keep him in that job as long as the snaps stay true, because the alternative in October is a tryout. Depth that shows up at the exact moment it's needed is how a special teams unit earns its coordinator some slack.

New England is the other story worth sitting with. Drake Maye and the Patriots offense exploded in Week 5, and while the headline is the big afternoon, the meaning is smaller and more important: this is the first real evidence that New England is building around Maye rather than building around protecting him. That distinction changes what the Patriots call on third down, and it changes how defenses have to prepare for them. The check on it is a defense that can generate pressure without blitzing. If Maye's answers get slower under duress, the explosion was a matchup; if they don't, the Patriots found their quarterback's ceiling and it's higher than anyone in the division wants.

My verdict: the 49ers took the worst of Sunday. A linebacker facing discipline and a receiver facing a hamstring is two problems hitting the same roster on the same afternoon, and San Francisco's offense looked narrow even before Samuel walked off. Give me the Vikings and the Patriots as the teams leaving the week better than they entered it.

PFNN NFL Pick’em league
NFL Pick’em 2026
Think you can outpick the league?
Free to play · Climb the leaderboard · Earn bragging rights
Play for free →

Researched and drafted with Pro Football News Network's AI reporting system and reviewed under human editorial oversight.

Share: